Methyl 2-oxindole-5-carboxylate in stock Factory

Methyl 2-oxindole-5-carboxylate in stock Factory - Names and Identifiers

Name	Methyl oxindole-5-carboxylate
Synonyms	METHYL OXINDOLE-5-CARBOXYLATE Methyl oxindole-5-carboxylate METHYL 2-OXINDOLE-5-CARBOXYLATE Methyl 2-Oxindole-5-Carboxylate METHYL 2-OXINDOLINE-5-CARBOXYLATE Methyl 2-oxo-5-indolinecarboxylate Methyl 2-oxoindoline-5-carboxylate methyl 2-oxo-2,3-dihydro-1H-indole-5-carboxylate Methyl 2-oxindole-5-carboxylate in stock Factory 2-OXO-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER
CAS	199328-10-4
InChI	InChI=1/C10H9NO3/c1-14-10(13)6-2-3-8-7(4-6)5-9(12)11-8/h2-4H,5H2,1H3,(H,11,12)

Methyl 2-oxindole-5-carboxylate in stock Factory - Physico-chemical Properties

Molecular Formula	C10H9NO3
Molar Mass	191.18
Density	1.283±0.06 g/cm3(Predicted)
Melting Point	192-199
Boling Point	405.6±45.0 °C(Predicted)
Flash Point	199.1°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	8.67E-07mmHg at 25°C
Appearance	Solid
Color	Very Dark Red to Very Dark Brown
pKa	13.43±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.572

Methyl 2-oxindole-5-carboxylate in stock Factory - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
Hazard Note	Harmful

Methyl 2-oxindole-5-carboxylate in stock Factory - Reference Information

application

methyl 5-carboxylate dihydroindol-2-one can be used as an intermediate in organic synthesis and a pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes.

preparation

under atmospheric pressure saturated with carbon monoxide, 5-iodo-2-hydroxyindole (17g) was refluxed with 2g
palladium diacetate, 18.2 triethylamine, 150mL methanol, 15mL dimethyl sulfoxide and 2.6gDPPP. After 24 hours, the reaction mixture was filtered to remove the catalyst and concentrate the filtrate. Use
30% ethyl acetate in hexane to chromatography the concentrate on silica gel. The part containing the product is concentrated and placed. The product was precipitated and collected by vacuum filtration to obtain 0.8g(7%) of methyl 5-carboxylate dihydroindol-2-one with
off-white solid.

Last Update：2024-04-09 21:01:54